Teleflex Commences Enrollment in CTO-PCI IDE Study
June 2, 2020—Teleflex Incorporated announced the first patient enrollment in a clinical study that will evaluate the performance of Teleflex coronary guidewires and specialty catheters in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) procedures, which is currently an investigational indication for these products.
Japanese Study Suggests Highly Skilled Operators Can Improve Reattempted CTO-PCI Success Rates
May 6, 2019—An analysis assessing reattempted percutaneous coronary intervention (PCI) strategy for chronic total occlusions (CTOs) after previous failed procedures in the Japanese CTO‐PCI Expert registry was published by Makoto Sekiguchi, MD, et al in Catheterization and Cardiovascular Interventions. The background of the study is that the development of complex techniques and algorithms are standardized for CTO‐PCI, but there is no appropriate strategy for CTO‐PCI after a failed procedure.
PROGRESS-CTO Registry Studies CTO PCI in Patients With and Without Previous CABG
March 26, 2019—Data from the PROGRESS-CTO international registry—which examined procedural outcomes of chronic total occlusion percutaneous coronary intervention (CTO PCI) in patients with previous coronary artery bypass grafting (CABG)—were published by Peter Tajti, MD, et al in Circulation: Cardiovascular Interventions.
FDA Approval Expands Indication for Medtronic's Resolute DES to Treat De Novo CTO
February 26, 2019—Medtronic announced FDA approval of an expanded indication for its Resolute drug-eluting stent (DES) platform for the treatment of patients with coronary artery disease who have de novo chronic total occlusions (CTOs).
Study Looks at Temporal Trends of PCI for CTO in Europe
October 9, 2018—Findings from an investigation of temporal trends in chronic total occlusion (CTO) interventions in Europe were published online by Nikolaos V. Konstantinidis, MD, et al on behalf of the Euro CTO Club in Circulation: Cardiovascular Interventions. The study focused on the evolution of practice, procedural outcomes, and in-hospital complications of percutaneous coronary intervention (PCI) to treat CTOs in Europe.
SoundBite Commences ACTIVE Coronary CTO Pivotal Clinical Study
September 21, 2018—SoundBite Medical Solutions Inc. announced commencement of the ACTIVE trial, which was recently approved by Health Canada to evaluate the safety and efficacy of the SoundBite Active Wire to cross coronary chronic total occlusions (CTOs).
Update Presented for PROGRESS-CTO International Registry
April 30, 2018—The Society for Cardiovascular Angiography and Interventions (SCAI) announced that a significant update to the PROGRESS-CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) international registry was presented at the 2018 SCAI scientific sessions, held April 25–28 in San Diego, California.
FDA Approves CTO Indication for Asahi's Corsair and Coronary Guidewires
April 2, 2018—Asahi Intecc Co., Ltd. announced that the US Food and Drug Administration has approved a chronic total occlusion (CTO) indication for its Corsair and Corsair Pro microcatheters and its coronary guidewires that include the MiracleBros series, Confianza series, Fielder series, and Gaia series.
Study Examines Prevalence, Presentation, and Treatment of Balloon Undilatable CTOs
January 29, 2018—Online in Catheterization and Cardiovascular Interventions, Peter Tajti, MD, et al published findings from an evaluation of the prevalence, clinical and angiographic characteristics, and procedural outcomes of percutaneous coronary interventions (PCIs) for balloon undilatable chronic total occlusions (CTOs) in the contemporary multicenter PROGRESS CTO Registry.
FDA Seeks to Strengthen Public Warnings and Recall Notifications; CDRH Outlines Strategic Priorities
January 18, 2018—US Food and Drug Administration (FDA) Commissioner Scott Gottlieb, MD, issued a statement on the agency's new policy steps for strengthening public warnings and notifications of recalls.
Use of the CrossBoss Catheter Studied for PCI of Chronic Total Occlusions
October 31, 2017—Findings from the CrossBoss First trial, which is evaluating the optimal initial strategy for crossing chronic total occlusions (CTOs) during percutaneous coronary intervention (PCI) procedures, were presented at TCT 2017, the 29th annual Transcatheter Cardiovascular Therapeutics scientific symposium being held October 30 to November 2 in Denver, Colorado.
Fully Transradial Approach Studied for PCI of CTO Applying the Hybrid Algorithm
September 11, 2017—Online in Circulation: Cardiovascular Interventions, Erik Jan Bakker, MD, et al published findings from a study that sought to assess technical success, complication rates, and procedural efficiency in a fully transradial approach (fTRA) and a transfemoral approach (TFA) in a large prospective European registry adopting the hybrid algorithm for chronic total occlusion (CTO) percutaneous coronary intervention (PCI).
OPEN-CTO Registry Evaluates Early Procedural and Health Status Outcomes After PCI for CTOs
August 11, 2017—Findings on early procedural and health status outcomes after chronic total occlusion (CTO) angioplasty in the OPEN-CTO registry were published online by James Sapontis, MD, et al in Journal of the American College of Cardiology (JACC): Cardiovascular Interventions.
Chronic Total Occlusions: What Is Clear and What Is Controversial?
With improvements in technique and patient selection, operators can safely and successfully treat patients with chronic total occlusions, but further research is needed to better answer some areas of controversy.
By Megha Prasad, MD, and Jeffrey W. Moses, MD
US Device Guide
This Device Guides offers a searchable, comprehensive listing of the available interventional cardiology devices in the United States.
European Device Guide
This Device Guides offers a searchable, comprehensive listing of the available interventional cardiology devices in Europe.