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November 2009
An Interview with Larry S. Dean, MD
The next SCAI president talks about many exciting developments in interventional cardiology, from a possible replacement for warfarin to the potential of aortic valve implantation, as well as health care reform.
What can you tell us about your facility and practice at
the University of Washington Medical Center?
The cardiovascular practice at the University of
Washington is through a service line called Regional
Heart Center that spans two institutions—the
Harborview Medical Center and the
University of Washington Medical
Center. The Regional Heart Center
includes not only the cardiology practice
but also cardiovascular surgery.
We have facilities for cardiac care in
both institutions, and our facility at
the University of Washington Medical
Center actually integrates the cardiology
practice with the cardiovascular
surgery practice so we have a common
clinic. This allows us to do consultations
very rapidly and easily. We implemented
this structure 10 years ago and have been moving
in the direction of further integration. One of the
issues surrounding heart centers is that they are mostly
hospital-based and, therefore, are not physician-based
practices. Aligning the physician practices with the hospital
is always a challenge.
Of the many trial results that have been announced
recently, which ones have caught your attention?
At the European Congress, there were presentations
centered on a potential replacement for warfarin that
could lead to a great improvement in anticoagulation
for patients with heart valves, atrial fibrillation, and
other anticoagulant indications. Many of these indications
currently require multiple laboratory tests and
very sophisticated follow-up; having a drug that does
not require all of these restrictions and that can be
easily administered would be of benefit.
Also, additional information is coming out about percutaneous valve replacement, specifically the aortic valve. We are involved in the PARTNER trial (Edwards Lifesciences, Irvine, CA), and I am very excited about it. The PARTNER trial has finished randomizing patients, but the follow-up will require a period of time for analysis.
There continue to be data published about the superiority of drug-eluting stents over bare-metal stents. There was some suggestion that drug-eluting stents may have an effect on mortality, which is something that has been lacking. A few years ago, there was concern that drug-eluting stents were causing various problems related to thrombosis. Since then, closer scrutiny of the data, as well as subsequent studies, have shown that the concern is not as great as initially reported.
What is the current focus of your
research energy, including your involvement
with the PARTNER trial?
The PARTNER trial has been taking
most of our energy for the past year. It
has been a very complex protocol
involving a very high-risk, elderly patient
population. It has also presented some interesting challenges;
how do you get a 90-year-old patient with severe
aortic stenosis to Seattle from the middle of Montana?
This can be a very significant challenge.
I am frequently asked, “What's exciting in interventional cardiology?” To be honest, another stent isn't all that exciting; there are many stents available, and there will always be more stents. But, transcatheter aortic valve implantation? It really has the potential to revolutionize the treatment of a certain patient population with aortic stenosis. I think it will be a game changer.
What coronary and cardiac developments do you
think need to be explored in the coming years?
One of the interesting things right now is that percutaneous
aortic valve implantation has “forced” cardiologists
and cardiovascular surgeons to work more closely
together than they have historically. I think that the
amount of the so-called hybrid procedures—those in
which surgeons are performing parts of the procedure
and cardiologists are doing other parts—will increase
during the next several years, especially when it comes
to percutaneous aortic valve implantation.
Interventional cardiologists and surgeons both excel at
specific aspects of procedures, and working together to treat individual patients might result in a more optimal
approach. For example, surgeons have an excellent conduit
(the internal mammary graft to the left anterior
descending artery); it basically lasts as long as the
patient is alive. Because vein grafts are not particularly
good for the other vessels, performing a combined procedure
in a patient with multivessel disease in whom a
left internal mammary artery graft is placed to the left
anterior descending artery with stents placed in the
other vessels might be an area of growth in the future.
As the specialties begin to work together more frequently,
the barriers surrounding the issue of “my turf
versus your turf” begin to come down.
I think it is important for cardiovascular surgeons and interventional cardiologists to work together to come up with the best therapy for patients and not focus on one specialty's therapy being better than the other, which has historically been the case.
You will be inducted as President of the Society for
Cardiac Angiography and Interventions (SCAI) at
next year's meeting. What will be the focus of the
SCAI next year?
The SCAI has been and will be closely following the
potential upcoming changes in health care reform. I suspect
that the SCAI will continue to focus on getting the
message out about what interventional cardiology is and
what benefits it offers, as well as working with Congress
to develop health care reform that addresses the issues
that interventional cardiology has as a whole with what
is being proposed. Advocacy and public relations have
been and will increasingly be a major focal point for the
SCAI. The SCAI is the voice of the practice of interventional
cardiology, particularly on the national scene.
What can you tell us about the STEMI Summit? What is
the most important message about ST-elevation
myocardial infarction (STEMI) that needs to be conveyed?
The Washington chapter of the American College of
Cardiology and the American Heart Association is doing
a combined program focused around the issue of doorto-
balloon time and treatment of STEMI. The STEMI
Summit will bring together physicians, both cardiologists
and noncardiologists, to discuss the issue of managing
STEMI in Washington State. The unique aspect of this
meeting is that most cardiologists do not get the opportunity
to deal with the emergency medical systems. This
is an example of a situation in which you need to have
all aspects of the process aligned to achieve successful
outcomes—the EMS team, the emergency department
physicians, and the cardiologists, as well as all of the
associated support staff and infrastructure, need to be
able to work together to make this happen. The STEMI
Summit is designed to allow all parties involved in this
process to have a discussion about what we are doing
that works well, what needs to be improved, and what
other programs are doing that makes them successful.
What do you consider to be the most rewarding procedures
you perform?
When I am called in to treat a patient who has a
STEMI, is in terrible pain, and is very unstable, and I and
my team work together (somewhat like an orchestra) to
open the vessel and can see immediate relief of discomfort
and improvement in clinical status, I know that I
have had an impact on the patient's outcome and life. I
think that is the most rewarding aspect of my job.
Would you like to comment on any specific issues that
concern you?
Washington State, like many states, is financially
strapped with big budget deficits. The State of
Washington funds insurance for several groups, including
state employees. The legislature has given coverage
decision control to a health technology committee
called the HTCC. They have been focusing on drugeluting
stents versus bare-metal stents and the impact
of these stents on outcomes. They have decided to
restrict the use of drug-eluting stents to a very narrow
group of patients. This has been going on for more
than 1 year, and they are very close to making their
final pronouncement. I do not know the exact level of
restriction, but it will not be what is on the package
insert and will not be what physicians are currently
doing from a clinical perspective.
This won't affect cardiologists directly because we do not get paid based on what stent we decide to place, but this will impact the hospitals in which we practice. This committee is going to restrict the use of stents and will not reimburse the hospital when a drug-eluting stent is placed, even if that stent might be what is best for the patient clinically. I would not be surprised to see similar groups begin to pop up throughout the country.
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