Neovasc's Reducer Demonstrates Improved Diastolic Function in Patients With Severe Angina


April 22, 2019—Neovasc Inc. announced that findings demonstrating that coronary sinus (CS) narrowing with the use of the company's Reducer device improves diastolic function and relaxation of the heart in patients with refractory angina were published online by Yishay Szekely, MD, et al in International Journal of Cardiology.

According to the company, the study's objective was to evaluate the impact of CS narrowing on stiffness and relaxation abilities of the left ventricle (diastolic function) in patients with myocardial ischemia and severe refractory angina treated with Reducer. The study demonstrated that treatment with Reducer may lead to improvement in diastolic function and echocardiographic parameters of left ventricular relaxation.

The company noted that the results of this trial may preclude the speculation that CS narrowing might adversely affect relaxation of the heart muscle. Additionally, Neovasc advised that the study demonstrated that Reducer not only improved angina status and quality of life of these patients but also resulted in a significant improvement in mean diastolic function.

The observed improvement in the relaxation properties of the heart are likely due to improved blood perfusion to ischemic territories of the heart muscle, which is a known effect of Reducer, stated Neovasc.

The Reducer device received European CE Mark approval for the treatment of refractory angina. The device is not yet approved for commercial use in the United States. The FDA granted Breakthrough Device designation to the Reducer device in October 2018.


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Cardiac Interventions Today (ISSN 2572-5955 print and ISSN 2572-5963 online) is a publication dedicated to providing comprehensive coverage of the latest developments in technology, techniques, clinical studies, and regulatory and reimbursement issues in the field of coronary and cardiac interventions. Cardiac Interventions Today premiered in March 2007 and each edition contains a variety of topics in a flexible format, including articles covering various perspectives on current clinical topics, in-depth interviews with expert physicians, overviews of available technologies, industry news, and insights into the issues affecting today's interventional cardiology practices.