Final 5-Year SORT OUT V Outcomes Published for Terumo's Biodegradable Nobori DES

 

December 21, 2017—Online in EuroIntervention, Lars Jakobsen, MD, et al reported the long-term safety and efficacy of the biodegradable polymer-coated biolimus-eluting Nobori stent (Terumo Interventional System) compared to the durable polymer-coated sirolimus-eluting Cypher stent (Cordis, a Cardinal Health Company) in the SORT OUT V trial.

As summarized in EuroIntervention, SORT OUT V randomized 2,468 patients 1:1 to the Nobori (n = 1,229) versus the Cypher stent (n = 1,239). The investigators used clinically driven event detection based on Danish registries.

The primary endpoint was a composite of safety (cardiac death, myocardial infarction, definite stent thrombosis) and efficacy (target vessel revascularization). The secondary endpoints were individual components of the primary endpoint.

The SORT OUT V investigators reported that at 5-year follow-up, the composite endpoint rate was found to be similar in patients treated with the two study stents (Nobori, 14.8% [182/1,229] vs Cypher, 15.8% [197/1,239]; odds ratio [OR], 0.93; 95% confidence interval [CI], 0.75–1.16; P = .53). The rates of definite stent thrombosis were also found to be similar in patients treated with the two study stents (Nobori, 1.9% [23/1,229] vs Cypher, 1.5% [18/1,239]; OR, 1.31; 95% CI, 0.70–2.47; P = .4), as were the other secondary endpoints.

At 5-year follow-up, the Nobori stent with a biodegradable polymer coating provided a similar safety and efficacy profile when compared to the durable polymer first-generation Cypher stent, concluded the investigators in EuroIntervention.

 

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Cardiac Interventions Today (ISSN 2572-5955 print and ISSN 2572-5963 online) is a publication dedicated to providing comprehensive coverage of the latest developments in technology, techniques, clinical studies, and regulatory and reimbursement issues in the field of coronary and cardiac interventions. Cardiac Interventions Today premiered in March 2007 and each edition contains a variety of topics in a flexible format, including articles covering various perspectives on current clinical topics, in-depth interviews with expert physicians, overviews of available technologies, industry news, and insights into the issues affecting today's interventional cardiology practices.